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Table 1 Concepts used when building the CRPS network in PathwayAssist (description in parenthesis).

From: Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in Complex Regional Pain Syndrome

Node Type Node Name
Complex Neuronal acetylcholine receptor[16, 98]
Functional Class NMDA receptor (N-methyl-D-aspartate receptor) [16, 98]
Protein CALCA (calcitonin/calcitonin-related polypeptide, alpha[46, 51]), IL1A (interleukin 1 alpha) [99], IL6 (interleukin 6) [13], NGFB (nerve growth factor, beta polypeptide), NGFG (nerve growth factor, gamma subunit) [79], NPY (neuropeptide Y[100]) [10], PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)[101]) [10], TAC1 (tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin) [10], TACR1 (tachykinin receptor 1), TNF (tumor necrosis factor) 24, BDKRB2 (bradykinin receptor B2[45, 56, 57]) [102], PTGS2 (prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)) [20], NTRK1 (neurotrophic tyrosine kinase, receptor, type 1) 72, TRPV1 (transient receptor potential cation channel, subfamily V, member 1), Ngfa (nerve growth factor, alpha), BDK (Bradykinin), VIP (vasoactive intestinal peptide)
Small Molecule glutamate, DMSO (Dimethyl sulfoxide), PGE2 (Prostaglandin E2), magnesium, noradrenaline, capsaicin, glucocorticoid, mannitol, pentoxifylline, naproxen, bisphosphonate, verapamil, morphine, ketamine, amitriptyline, clonidine, carbamazepine, nortriptyline, lidocaine, GABA (gamma-aminobutyric acid), ketanserin, infliximab, gabapentin, amantadine, lioresal, benzodiazepine, Baclofen, N-acetyl-cystein