Table 1 Concepts used when building the CRPS network in PathwayAssist (description in parenthesis).
Node Type | Node Name |
|---|---|
Complex | Neuronal acetylcholine receptor[16, 98] |
Functional Class | NMDA receptor (N-methyl-D-aspartate receptor) [16, 98] |
Protein | CALCA (calcitonin/calcitonin-related polypeptide, alpha[46, 51]), IL1A (interleukin 1 alpha) [99], IL6 (interleukin 6) [13], NGFB (nerve growth factor, beta polypeptide), NGFG (nerve growth factor, gamma subunit) [79], NPY (neuropeptide Y[100]) [10], PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)[101]) [10], TAC1 (tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin) [10], TACR1 (tachykinin receptor 1), TNF (tumor necrosis factor) 24, BDKRB2 (bradykinin receptor B2[45, 56, 57]) [102], PTGS2 (prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)) [20], NTRK1 (neurotrophic tyrosine kinase, receptor, type 1) 72, TRPV1 (transient receptor potential cation channel, subfamily V, member 1), Ngfa (nerve growth factor, alpha), BDK (Bradykinin), VIP (vasoactive intestinal peptide) |
Small Molecule | glutamate, DMSO (Dimethyl sulfoxide), PGE2 (Prostaglandin E2), magnesium, noradrenaline, capsaicin, glucocorticoid, mannitol, pentoxifylline, naproxen, bisphosphonate, verapamil, morphine, ketamine, amitriptyline, clonidine, carbamazepine, nortriptyline, lidocaine, GABA (gamma-aminobutyric acid), ketanserin, infliximab, gabapentin, amantadine, lioresal, benzodiazepine, Baclofen, N-acetyl-cystein |