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Figure 3 | Journal of Biomedical Discovery and Collaboration

Figure 3

From: Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in Complex Regional Pain Syndrome

Figure 3

The entire CRPS pathogenesis. Starting point: sympathetic dysregulation. Mediated by NFκB, a trigger that induces sympathetic dysregulation can induce the entire pathogenesis of CRPS. SP = Substance P, CGRP = Calcitonin Gene-related Protein, VIP = Vasoactive Intestinal Protein, NPY = Neuropeptide Y, NPY-Y1-R = Neuropeptide Y-Y1 Receptor, NEP = Neutral-Endopeptidase, ACE = Angiotensin Converting Enzyme, SMP = Sympathetically Maintained Pain, NO = Nitric Oxide, iNOS = inducible Nitric Oxidase, ONOO = peroxynitrite

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Journal of Biomedical Discovery and Collaboration

ISSN: 1747-5333